Glenn M. Chertow
Publication Details
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beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis.
Kidney Int. 2001; (3): 990-1002
A local inflammatory reaction to beta(2)-microglobulin (beta(2)m) amyloid deposits by monocytes/macrophages is a characteristic histologic feature of dialysis-related amyloidosis (DRA). Since beta(2)m modified with advanced glycation end products (AGE-beta(2)m) is a major constituent of amyloid in DRA, we tested the hypothesis that AGE-beta(2)m affects apoptosis and phenotype of human monocytes.
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