Ronald L. Dalman MD, the Walter C. and Elsa R. Chidester Professor of Surgery
Publication Details
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Comparison of cell-type-specific vs transmural aortic gene expression in experimental aneurysms.
J Vasc Surg. 2005; (5): 844-52
Abdominal aortic aneurysm (AAA) progression and disease resistance are related to mural cellularity; adventitial macrophages and neocapillaries predominate in larger, advanced aneurysms, whereas smaller AAAs have fewer macrophages and retain more medial smooth muscle cells (SMCs). Expression analysis of mRNA derived from the entire aorta may mask the role that specific cell types play in modulating disease progression. We used laser capture microdissection (LCM) to isolate SMC and macrophage-predominant mural cell populations for gene expression analysis in variable-flow AAA.
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