Robert Fisher

Publication Details

  • Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

    Wu J, Javedan SP, Ellsworth K, Smith K, Fisher RS. BMC Neurosci. 2001: 2 18

    Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spreading depression (SD). This may serve as an in vitro model of febrile seizures.

    PubMedID: 11747470

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