Victor W. Henderson
Publication Details
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Alzheimer disease: high intensity periventricular white matter alterations on magnetic resonance imaging.
Bull Clin Neurosci. 1988: 137-147
Confluent or focal periventricular white matter hyperintensities on T2-weighted MR images was found in 75% (15/20) of elderly demented patients who met NINCDS-ADRDA criteria for probable Alzheimers disease. Sulcal enlargement was significantly associated with confluent and focal alterations, but MR findings failed to distinguish among clinical subtypes, implying the lact of diagnostic or clinical significance for these white matter alterations on MR in this population. Periventricular white matter hyperintensity, whether reflecting Alzheimers pathology or a nonspecific finding unrelated to this disorder, need not dissuade the clinicial from a diagnosis of Alzheimers disease.
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