Victor W. Henderson
Publication Details
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In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging.
Arch Gen Psychiatry. 2000; (1): 47-53
The basal ganglia contain the highest levels of iron in the brain, and postmortem studies indicate a disruption of iron metabolism in the basal ganglia of patients with Alzheimer disease (AD). Iron can catalyze free radical reactions and may contribute to oxidative damage observed in AD brains. Treatments aimed at reducing oxidative damage have offered novel ways to delay the rate of progression and could possibly defer the onset of AD. Brain iron levels were quantified in vivo using a new magnetic resonance imaging method.
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