David Liang, MD, PhD

Publication Details

• Alterations in left ventricular curvature and principal strains in dilated cardiomyopathy with functional mitral regurgitation.

  Tibayan FA, Lai DT, Timek TA, Dagum P, Liang D, Zasio MK, Daughters GT, Miller DC, Ingels NB. J Heart Valve Dis. 2003; 12 (3): 292-9

  Functional mitral regurgitation (FMR) is increasingly recognized as a left ventricular (LV) disease. Dilated cardiomyopathy (DCM) is commonly accompanied by FMR and reduction of LV torsion. Therapeutic targets for DCM include LV size reduction, altered LV shape, elimination of MR, and increasing LV torsion. It was hypothesized that, in addition to increasing LV size, DCM with FMR would alter normal LV shape and reduce and alter the direction of principal strains across the LV wall. This hypothesis was tested by measuring changes in epicardial and endocardial 2-D principal strains and regional radii of curvature accompanying tachycardia-induced cardiomyopathy in ovine hearts.

  PubMedID: 12803327