Glenn M. Chertow
Publication Details
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Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury.
Nephrol Dial Transplant. 2010; (1): 102-7
In critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction equations overestimate kidney function in patients with acute kidney injury and that improved estimates could be obtained by methods incorporating changes in creatinine generation and fluid balance.
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