Griffith Harsh
Publication Details
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Effects of tumor suppressor gene (p53) on brain tumor angiogenesis and expression of angiogenic modulators.
Anticancer Res. 2004 Jan-Feb; (1): 1-10
p53 retarded tumor growth by several known mechanisms, including suppression of cell proliferation and inhibition of tumor angiogenesis. Vascular endothelial growth factors (VEGF) and angiopoietins (Ang-1, Ang-2) are major angiogeneic modulators. The current study examined the effect of p53 on the expression of these factors in conjunction with tumor growth and vascular formation.
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