Carlos O. Esquivel
Publication Details
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Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Transplantation. 2007; (6): 778-85
Apoptosis of hepatocytes contributes to many forms of liver pathology and can compromise liver function. Hepatocytes have been shown to require mitochondrial disruption to execute apoptosis, a process that is controlled by members of the Bcl-2 family. Bid is a proapoptotic Bcl-2 family member that is cleaved to its active form, tBid, by caspase 8 and granzyme B. Studies in the Bid-deficient mouse have established that hepatocytes require Bid to undergo apoptosis.
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