Jonathan S. Berek
Publication Details
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Evidence for a unifocal origin in familial ovarian cancer.
Am J Obstet Gynecol. 1996; (4): 1102-6; discussion 1106-8
The purpose of this investigation was to determine the pattern of loss of heterozygosity in multiple tumor sites from familial ovarian cancer cases. If ovarian cancer arises focally in one ovary and then metastasizes to other sites, a similar pattern should be seen in all tumor sites. However, if ovarian cancer arises multifocally throughout the peritoneal cavity, a different pattern of loss would be expected among the different sites.
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