Lawrence Steinman
Publication Details
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Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis.
Int Immunol. 1999; (2): 289-96
Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma.
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