Geoffrey Kerchner
Publication Details
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Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI.
Neurology. 2010; (15): 1381-7
In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial loss of the CA1 pyramidal neurons themselves. In this cross-sectional study, we tested whether tissue loss in the CA1 apical neuropil layer can be observed in vivo in patients with mild AD.
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