Juergen K. Willmann, M.D.

Publication Details

• Ultrasound molecular imaging contrast agent binding to both E- and P-selectin in different species.

  Bettinger T, Bussat P, Tardy I, Pochon S, Hyvelin JM, Emmel P, Henrioud S, Biolluz N, Willmann JK, Schneider M, Tranquart F. Invest Radiol. 2012; 47 (9): 516-23

  Ultrasound molecular imaging is increasingly used in preclinical studies to measure the expression of vascular markers during inflammation process. In this context, a new ultrasound contrast agent functionalized with a recombinant P-selectin glycoprotein ligand-1 analogue (rPSGL-Ig) was developed (MBrPSGL-Ig). This agent was assayed in vitro and in vivo to evaluate its binding performance and potential to image expression of inflammatory markers E- and P-selectin. Performance of this newly developed agent was compared with that of antibody (MBAb) or sialyl Lewis X (MBsLe) containing microbubbles and with control microbubbles (MBC).

  PubMedID: 22814589