Joseph C. Wu
Publication Details
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Novel minicircle vector for gene therapy in murine myocardial infarction.
Circulation. 2009; (11 Suppl): S230-7
Conventional plasmids for gene therapy produce low-level and short-term gene expression. In this study, we develop a novel nonviral vector that robustly and persistently expresses the hypoxia-inducible factor-1 alpha (HIF-1alpha) therapeutic gene in the heart, leading to functional benefits after myocardial infarction.
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