D. Craig Miller, M.D.
Publication Details
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Transmural left ventricular shear strain alterations adjacent to and remote from infarcted myocardium.
J Heart Valve Dis. 2006; (2): 209-18; discussion 218
In some patients, dysfunction in a localized infarct region spreads throughout the left ventricle to aggravate mitral regurgitation and produce deleterious global left ventricular (LV) remodeling. Alterations in transmural strains could be a trigger for this process, as these changes can produce apoptosis and extracellular matrix disruption. The hypothesis was tested that localized infarction perturbs transmural strain patterns not only in adjacent regions but also at remote sites.
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