William Fearon, MD

Publication Details

• Coronary microcirculatory resistance is independent of epicardial stenosis.

  Yong AS, Ho M, Shah MG, Ng MK, Fearon WF. Circ Cardiovasc Interv. 2012; 5 (1): 103-8, S1-2

  Recent studies show that coronary microcirculatory impairment is an independent predictor of poor outcomes in patients with cardiovascular disease. However, controversy exists over whether microcirculatory resistance, a measure of coronary microcirculatory status, is dependent on epicardial stenosis severity. Previous studies demonstrating that microcirculatory resistance is dependent on epicardial stenosis severity have not accounted for collateral flow in their measurement of microcirculatory resistance. We investigated whether the index of microcirculatory resistance is independent of epicardial stenosis by comparing the index of microcirculatory resistance (IMR) levels in patients before and after percutaneous coronary intervention (PCI).

  PubMedID: 22298800