Lawrence Steinman
Publication Details
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Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Arthritis Res Ther. 2008; (5): R119
Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, little is known about their origins and contribution to pathogenesis. Citrullination is the post-translational conversion of arginine to citrulline by peptidyl arginine deiminase, and increased citrullination of proteins is observed in the joint tissue in RA and in brain tissue in multiple sclerosis (MS).
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