James D. Brooks
Publication Details
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Small prostate size and high grade disease--biology or artifact?
J Urol. 2011; (6): 2108-11
Prior radical prostatectomy series have shown an inverse association between prostate size and high grade cancer. It has been suggested that smaller size prostates arise in a low androgen environment, enabling development of more aggressive cancer. We propose that this observation is the result of ascertainment bias driven by prostate specific antigen performance.
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