Lawrence Steinman
Publication Details
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Suppression of autoimmunity via microbial mimics of altered peptide ligands.
Curr Top Microbiol Immunol. 2005: 55-63
Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunity could therefore be modulated via microbial immunity, which may account for relapse and remission of ongoing disease.
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