Nicholas Leeper
Publication Details
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Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway.
J Surg Res. 2002; (2): 118-23
Elevated levels of interleukin-6 (IL-6) have been identified in a variety of systemic inflammatory states that are associated with endothelial barrier dysfunction, but the specific effect of IL-6 on endothelial permeability and the mechanism of action have not been fully examined. The current study evaluated the effect of IL-6 on endothelial permeability and on the distribution of the tight junctional protein ZO-1 and cytoskeletal actin. We also assessed the role of protein kinase C (PKC) in this process.
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