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Inner ear microendoscopy -- Developing techniques for minimally-invasive imaging of inner ear microanatomy and neural pysiology. Applications include improved cochlear implant development, inner ear regenerative techniques, inner ear surgery, and auditory physiology. Microsurgical robotics -- Developing scalable microsurgical instrumentation and robotic techniques for use in head and neck surgery. Surgical Simulation -- Immersive environment for temporal bone surgical simulation.

http://med.stanford.edu/ohns/research/labs_chang.html

Sensorineural hearing loss affects more than 30 million people worldwide and the most common underlying pathology is loss of sensory hair cells, the mechanoreceptors of the inner ear. Loss of these specialized cells is permanent in mammals and regeneration is limited/non-existent. Recently stem cell-like cells have been isolated from the mammalian inner ears. Our research group is interested in identifying signals that maintain the stem cell population and the stem cell niche in the mammal..

Multi- modality treatment of Head and Neck Cancer Phase 1 clinical trials

Advanced MRI imaging for laryngeal cancer and swallowing disorders; applications of robotics in microlaryngeal surgery; high speed digital imaging of vocal fold vibration; the effects of hormones and anabolic steroids on vocal function.

Effects of ultra low dose cytokines on safety and outcome of patients with advanced, operable Head & Neck Cancer.

- Visuohaptic virtual environments for interactive planning tools for preoperative surgery simulation in Cranio-Maxillofacial Surgery, Maxillofacial Trauma and Dental Implantology - Molecular basis of maxillo-mandibular bone regeneration and oral mucosal changes - Excellence and Diversity in Academic Medicine and Medical Education

+Virtual reality for diagnosing and treating skin cancers. +Non-invasive imaging including confocal microscopy for diagnosing and treating skin cancers. +Wound healing including scars/keloids +Cosmetic laser tissue interaction +Minimally invasive procedures for the ageing face

Middle ear mechanics, correction of hearing loss, development and evaluation of middle ear prosthesis; creative strategies for correcting various types of hearing loss using surgery in temporal bone models and humans. Research in new methods to surgically correct tongue collapse in sleep apnea. Research to improve facial muscle movement following facial nerve injury using surgical techniques.

Microsurgical treatment of tumors of the brain, spinal cord, pituitary gland and skull base; Radiosurgery of tumors; Molecular biology of brain tumors.

- Characterization of ion transport activity in sinonasal epithelium - Optimization of mucosal wound healing in a rabbit model of sinus surgery - Clinical outcomes in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery - Effect of intraoperative local anesthetic use on post operative pain in patients undergoing endoscopic sinus surgery

Development of innovative surgical methods, via the cranial base, to expose inaccessible intracranial disease. Surgical simulation and robotics. Evidence based outcomes analysis in acoustic neuroma and other tumors of the cerebellopontine angle. History of tobacco advertising with false reassurance of healthfulness (see tobacco.stanford.edu). Medical history - especially the history of otology, neurosurgery, deafness, and quackery.

1) New therapeutic approaches for head and neck cancer, including immune stimulation possibilities (IRX-2 protocol), integration of biological modifiers, and, eventually, genetic approaches. 2) Head and neck cancer stem cells: identification, characterization, control--in conjunction with the Irv Weissman and Michael Clarke labs in the Stem Cell Institute 3) Development of innovative surgical methods at the anterior cranial base

Dr. Kim's current research interests include surgical reconstruction of Graves' eye disease, improving outcomes following orbital and adnexal trauma, and developing novel treatment options for introcular malignancies (e.g. retinoblastoma, uveal melanoma).

1 - Airway and swallow evaluation of infants with micrognathia. 2 - Investigating the vascular anatomy of the post cricoid region. 3 - Conducting a long term follow-up of children who have had powered intracapsular tonsillectomy

My laboratory research interest focusses on the identification of serum markers for tumor hypoxia and for prognosis in patients with head and neck or lung cancers. I am also conducting a number of clinical trials specifically in patients with these tumors.

--CMV Associated Hearing Loss --Newborn Hearing Screening --Sensorineural Hearing loss --Postoperative tonsillectomy care --Ankyloglossia --Steroids in otolaryngology --vocal cord paralysis --diagnosis of gastropharyngeal reflux

1. Evidence-based medicine in Facial Plastic Surgery The primary goal of this research program is to develop a higher standard of care for facial plastic surgery patients. One example of this is the evelopment of prospective studies that examine the efficacy of new or existing surgical techniques in facial plastic surgery. One clinical problem we have already begun to examine is nasal obstruction. 2. Examination of facial nerve injury and biological correlates of functional recovery.

Kari Nadeau, MD, PhD, Allergy, Immunology and Asthma Our research interests in the laboratory focus on the role of human T cells, specifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the mechanisms of action of regulatory T cell suppressive function. We study how pollution, such as diesel exhause, disrupt Treg suppressive function and how chemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.

Clinical Interests: general oncology, head and neck cancer Research Interests: chemoprevention trials and combined modality approaches to head and neck cancer

My laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells.

Clinical research interest in improving cosmetic outcomes for parotid and thyroid surgery, innovative techniques for anterior skull base surgery, and improving outcomes for head and neck cancer patients.