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Yoon-Jae Cho

Academic Appointments

Contact Information

  • Clinical Offices
    Pediatric Neurology 730 Welch Rd Ste 206 Palo Alto, CA 94304
    Tel Work (650) 723-0993 Fax (650) 721-6350
  • Academic Offices
    Personal Information
    Email
    Alternate Contact
    Gayla Weng Administrative Assistant Tel Work 650-721-5889

Professional Overview

Clinical Focus

  • Neurology - Child Neurology
  • Neuro-oncology

Honors and Awards

  • co-Chair, Biology Committee, Pediatric Brain Tumor Consortium (2012-)
  • Philip R. Dodge Young Investigator Award, Child Neurology Society (2012)
  • Beirne Faculty Scholar in Pediatirc Neuro-oncology, Stanford University (2011-)
  • Scholar, St. Baldrick's Foundation (2011-)
  • Faculty Development Award, Shore Fellowship Program for Scholars in Medicine, Harvard Medical School (2009-2011)
  • Young Investigator Award, Pediatric Brain Tumor Foundation (2007)
View All 7honors and awards of Yoon-Jae Cho

Professional Education

Fellowship: Children's Hospital Boston MA (2008)
Board Certification: Neurology - Child Neurology, American Board of Psychiatry and Neurology (2009)
Residency: Children's Hospital Boston MA (2007)
Residency: Children's Hospital Oakland CA (2004)
Internship: Children's Hospital of Pittsburgh PA (2003)
Medical Education: Oregon Health Science University OR (2002)
View All 7

Postdoctoral Advisees

Yujie Tang

Graduate & Fellowship Program Affiliations

Scientific Focus

Current Research Interests

Overview
My laboratory studies childhood brain tumors with a particular focus on medulloblastoma, the most common malignant brain tumor in children. We utilize a mix of computational/genomic and cell biological approaches to 1) understand the molecular and cellular basis of medulloblastoma, 2) generate new treatment strategies for patients diagnosed with this disease and 3) inform the current and next generation of medulloblastoma clinical trials.

Current projects:
Functional annotation of the medulloblastoma genome
We are currently combining genome-wide RNAi with chemical biology and chemical genomic screens to systematically define the functional consequence of genes and biological pathways enriched in the most clinically aggressive subtypes of this disease.

Leveraging expression of neurotransmitter receptors for therapeutic and diagnostic purposes in medulloblastoma
Through our prior genomic analysis of medulloblastoma, we have identified a high level of expression of neurotransmitter receptors in certain subtypes of these tumors. We are now investigating whether modulation of their activity via pharmacological and genetic manipulation results in a therapeutic response. We are also taking advantage of their expression to develop biomarker / bioimaging tools for use in the clinic.

Identification of nucleotide level events in medulloblastoma using high-throughput whole exome sequencing
Using whole-exome and genome sequencing, we have identified a number of previously unreported mutations in medulloblastoma. We are functionally characterizing several of these using in vitro and in vivo assays and determining whether such events carry clinical significance in terms of prognosis, treatment response or potential for targeted therapy.

Publications

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Publication Topics

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