Shirit Einav
Academic Appointments
- Assistant Professor, Medicine - Infectious Diseases
- Member, Bio-X
- Member, Child Health Research Institute
- Assistant Professor, Microbiology & Immunology
Key Documents
Contact Information
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Clinical Offices
Grant Building Rm S136 300 Pasteur Drive Stanford, CA 94305
- Academic Offices
Personal Information Email Tel (650) 723-8656Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Infectious Disease
Administrative Appointments
- Assistant Professor (UTL), Department of Medicine, Department of Microbiology and Immunology (2011 - present)
- Instructor of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine (2009 - 2011)
- Infectious Diseases Fellowship, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine (2004 - 2008)
- Postdoctoral Fellowship. Supervisor: Dr. Jeffrey S. Glenn, Division of Gastroenterology and Hepatology, Stanford University School of Medicine (2003 - 2004)
- Medical Internship and Residency, Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (1999 - 2002)
- Research Studentship, Supervisor: Dr. Michael C. Carroll., Brigham and Womens Hospital and the Center for Blood Research, Harvard Medical School, Boston, MA (1999 - 1999)
Honors and Awards
- Stanford Bio-X Interdisciplinary Initiative Program Award, Stanford, Bio-X (2012)
- IDSA 2012 IDWeek Investigator Award, Infectious Diseases Society of America (IDSA) (2012)
- IDSA 2009 Program Committee Choice Award, Infectious Diseases Society of America (IDSA) (July 2009)
- DDC Pilot/Feasibility Award, Stanford Digestive Disease Center (DDC) (March 2009)
- ITI Young Investigator Innovation Award, Stanford Institute for Immunity, Transplantation, and Infection (ITI) (Dec 2008)
- Mentored Clinical Scientist Development Award (KO8), NIH/NIAID (Sept 2008 - July 2013)
Professional Education
| Fellowship: | Stanford University - Infectious Diseases CA (2009) |
| Board Certification: | Infectious Disease, American Board of Internal Medicine (2006) |
| Internship: | Beth Israel Deaconess Med Center/Harvard MA (2000) |
| Medical Education: | Sackler School of Medicine, Israel (1999) |
| BA: | Sackler School of Medicine, Israel, Medical sciences (1994) |
| MD: | Sackler School of Medicine, Israel, Medicine (1999) |
Internet Links
Scientific Focus
Current Research Interests
My lab focuses on better understanding virus-host protein-protein interactions. We combine novel proteomic approaches, including high-fidelity microfluidics platforms, with molecular virology, biochemical, and functional genomic approaches for identification of host partners conservatively required by various viruses and development of broad-spectrum host-centered antiviral strategies with a high genetic barrier for resistance. We focus on Flaviviridae (currently, hepatitis C (HCV) and dengue) as well as HIV.
Ongoing projects:
1. Mechanisms by which Flaviviridae and HIV hijack intracellular membrane trafficking pathways for mediating viral assembly, envelopment, release, and direct cell-to-cell spread. We have identified several sorting signals within Flaviviridae proteins that are involved in mediating key steps in the late stages of the viral cycle. We are currently mapping the interaction networks of these signals with human proteins, and investigating the functional relevance, regulatory mechanisms, and inhibition of these interactions. Additional projects involve interactions with cytoskeleton dynamics proteins, ESCRT machinery and more.
2. Mechanisms of HCV-related cancer. Chronic HCV infection is a major cause of hepatocellular carcinoma and is also associated with non-Hodgkin lymphoma. We study virus-host interactions involved in facilitating viral persistence thereby promoting HCV-related oncogenesis.
3. Molecular mechanisms underlying HCV-HIV co-infection.
4. Furthering novel high-throughput proteomic technologies for screening and mapping virus-host interactomes and for screening small molecule libraries for inhibitors of protein-protein interactions.
Publications
- Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly. PLoS Pathog. 2012; (8): e1002845
- A small molecule inhibits HCV replication and alters NS4B's subcellular distribution. Antiviral Res. 2010; (1): 1-8
- Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010; (2): e1000764
- The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010; (1): 65-74
- Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008; (9): 1019-27
- The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection. Hepatology. 2008; (3): 827-35
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