Manuel Amieva
Academic Appointments
- Associate Professor, Pediatrics - Infectious Diseases
- Associate Professor, Microbiology & Immunology
Key Documents
Contact Information
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Clinical Offices
Pediatric Infectious Disease 730 Welch Rd 2nd Floor MC 5884 Palo Alto, CA 94304 Tel Work (650) 721-5805 Fax (650) 725-8040Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Infectious Diseases, Pediatric
- Pediatric Infectious Disease
Professional Education
| Board Certification: | Pediatrics, American Board of Pediatrics (2003) |
| Board Certification: | Pediatric Infectious Disease, American Board of Pediatrics (2005) |
| Medical Education: | Stanford University School of Medicine CA (1997) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. We are also studying how various bacteria cross and invade the epithelium. For example, we recently found that Listeria monocytogenes targets a specialized subset of cell-cell junctions at the tip of the intestinal villi to find its receptor for invasion. We are interested in determining whether this mode of gastrointestinal invasion of the epithelium is also used by other gastrointestinal pathogens.
Publications
- Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest. 2013; (1): 479-92
- ChePep controls Helicobacter pylori Infection of the gastric glands and chemotaxis in the Epsilonproteobacteria. MBio. 2011; (4)
- Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog. 2011; (5): e1002050
- Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion. PLoS Pathog. 2010; (5): e1000900
- Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche. PLoS Pathog. 2009; (5): e1000407
- Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008; (1): 306-23
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