Joshua M. Spin
Academic Appointments
- Clinical Instructor, Medicine - Cardiovascular Medicine
- Basic Life Science Research Associate, Medicine - Cardiovascular Medicine
Key Documents
Contact Information
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Clinical Offices
Cardiovascular Medicine 300 Pasteur Dr H2157 MC 5233 Stanford, CA 94305 Tel Work (650) 725-8246 Fax (650) 724-4034
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Aortic Disease
- Marfan Syndrome and Aortic Disorders
- Cardiovascular Disease
Professional Education
| Fellowship: | Stanford University School of Medicine CA (2003) |
| Internship: | Stanford University School of Medicine CA (1998) |
| Residency: | Stanford University School of Medicine CA (2000) |
| Board Certification: | Cardiovascular Disease, American Board of Internal Medicine (2003) |
| Medical Education: | Boston University School of Medicine MA (1997) |
| BA: | Cornell University, Biophysics (1989) |
Scientific Focus
Current Research Interests
Dr. Spin is pursuing fundamental issues relating to smooth muscle cell (SMC) biology. SMCs play crucial roles in vascular development, homeostasis, and disease. He has examined gene expression within the vascular wall, identifying patterns and pathways that characterized atherogenesis. He has also studied the biology of differentiation and phenotypic switching in vascular SMCs, first identifying differentially regulated genes associated with SMC lineage determination, and then focusing on the epigenetic regulation of SMC differentiation state. Most recently he has examined the role of microRNAs in the regulation of SMC phenotype, and studied the biology of aortic aneurysm development in mouse models.
Publications
- In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol. 2012; (1): 92-102
- Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. J Clin Invest. 2012; (2): 497-506
- MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med. 2012; (122): 122ra22
- Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling. Cardiovasc Res. 2012; (2): 147-55
- miR-29b participates in early aneurysm development in Marfan syndrome. Circ Res. 2012; (2): 312-24
- Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol. 2011; (4): H1461-70
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