Joshua W. Knowles
Academic Appointments
- Instructor, Medicine - Cardiovascular Medicine
Key Documents
Contact Information
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Clinical Offices
Cardiovascular Medicine 300 Pasteur Dr MC 5406 CV 158 Stanford, CA 94305 Tel Work (650) 723-1431 Fax (650) 725-2178
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cardiology
- Cardiovascular Medicine
- Insulin Resistance
- Familial Hypercholesterolemia
- Cardiomyopathy, Hypertrophic
Honors and Awards
- National Fellow to Faculty Transition Award, AHA (7/1/10-7/1/15)
- Alderman Award for Excellence in Clinical Research, Stanford Cardiovascular Medicine (2008, 2009)
- Fellowship Award, Future Leaders in CV Medicine (2006)
- Dean's Fellowship, Stanford (2005)
Professional Education
| Fellowship: | Stanford Hospital and Clinics CA (2010) |
| Residency: | Stanford Hospital and Clinics CA (2005) |
| Board Certification: | Cardiovascular Medicine, American Board of Internal Medicine (2010) |
| Medical Education: | University of North Carolina - Chapel Hill NC (2003) |
| PhD: | University of North Carolina, Chapel Hill, Genetics and Molecular Biology (2001) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (2006) |
Community and International Work
- The FH Foundation, US
- Arbor Free Clinic, Bay Area
Scientific Focus
Current Research Interests
The overall theme of my work is to understand the genetic basis of complex cardiovascular diseases such as coronary disease and insulin resistance. Currently, I am involved in genome wide association (GWA) studies of coronary disease through the NIH-funded ADVANCE study and of insulin resistance through the international GENESIS project. After using the GWA approach to discover and validate interesting candidate genes, I hope to explore the biology underlying these genes and pathways using cell culture and in vivo model systems. I am also using iPSC technology (induced pluripotent stem cells) to develop model systems for the study of insulin resistance through the NIH-funded GENESiPS project.
I also have a strong interest in developing tools to help translate newly emerging genetic data into clinical practice and am currently the PI of a randomized trial where we are examining whether we can improve patient coronary disease risk factor profiles by giving them information about their inherited risk of coronary disease.
Clinically, I am interested in the care of patients with inherited cardiovascular conditions. In particular I am focused on individuals with Familial Hypercholesterolemia. I also have an interest in treating Hypertrophic Cardiomyopathy. I take care of these patients in the Stanford Center for Inherited Cardiovascular Disease.
Publications
- Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 2013; (16): 1677-91
- Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes. 2013
- Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013; (1): 25-33
- Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. Metabolism. 2013; (4): 548-53
- Exploring predisposition and treatment response--the promise of genomics. Prog Cardiovasc Dis. 2012 Jul-Aug; (1): 56-63
- Randomized trial of personal genomics for preventive cardiology: design and challenges. Circ Cardiovasc Genet. 2012; (3): 368-76
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