Hugh O'Brodovich
Academic Appointments
- Professor, Pediatrics
- Member, Child Health Research Institute
Key Documents
Contact Information
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Clinical Offices
Lucile Packard Children's Hospital 725 Welch Rd Palo Alto, CA 94304 Tel Work (650) 497-8000 Fax (650) 725-7419Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-5104Alternate Contact Donna Schurr Executive Assistant to the Chair of Pediatrics Email Tel Work 650-723-5104Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Pediatric Pulmonary
- Pulmonary Medicine/Cystic Fibrosis, Pediatric
Administrative Appointments
- Chairman of Pediatrics, Stanford University (2008 - present)
- Physician in Chief, Lucile Packard Children's Hospital (2008 - present)
- Director, Child Health Research Institute at Stanford, Stanford University (2011 - present)
- Paediatrician in Chief, Hospital for Sick Children (SickKids) (1996 - 2006)
- Chairman of Pediatrics, University of Toronto (1996 - 2006)
Honors and Awards
- President, Fleischner Society (2007)
- Fellow, Canadian Academy of Health Sciences (2006)
- Edwin L Kendig Award, American Academy of Pediatrics/American College of Chest Physicians (2005)
- Inaugural President, Pediatric Chairs of Canada (2002-2004)
- Scientific Accomplishment Award, American Thoracic Society (2001)
Professional Education
| Board Certification: | Pediatric Pulmonary, American Board of Pediatrics (1986) |
| Fellowship: | Columbia University College of Physicians & Surgeons NY (1981) |
| Board Certification: | General Pediatrics, American Board of Pediatrics (1980) |
| Medical Education: | University of Manitoba, Manitoba Canada (1975) |
| FRCPC: | Royal Coll Phys & Surg, Paediatric Respiratory Medicine (1989) |
| FRCPC: | Royal College Phys & Surg, Paediatrics (1980) |
Internet Links
Scientific Focus
Current Research Interests
We wish to develop new therapies to prevent and treat the respiratory distress syndrome (RDS) and its sequelae, bronchopulmonary dysplasia (BPD). In the pursuit of this goal my laboratory has conducted research on how the lungs airspaces become fluid filled (mechanisms of pulmonary edema) and how airspace fluid is cleared under both physiologic (fetal lung liquid at birth) and pathophysiologic (pulmonary edema) conditions. Since the rate limiting step in airspace fluid clearance is the active transport of Na+ by distal lung epithelium, our studies had investigated the effect of lung maturity, mediators and hormones on the pre and post-translational regulation of the epithelial Na+ channel (ENaC). My current research involves a population based study to discover the genetic influences on the development of BPD.
Publications
- Progress in understanding the genetics of bronchopulmonary dysplasia. Semin Perinatol. 2013; (2): 85-93
- Risk of bronchopulmonary dysplasia by second trimester maternal serum levels of alpha-fetoprotein, human chorionic gonadotrophin and unconjugaged Estriol Pediatric Research. 2012; (4): 399-406
- Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury Am J Physiol Lung Cell Mol Physiol. 2011: L648-L658
- Long-term terbutaline exposure stimulates alpha1-Na+-K+-ATPase expression at posttranscriptional level in rat fetal distal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010; (1): L96-L104
- NHLBI training workshop report: The vanishing pediatric pulmonary investigator and recommendations for recovery. Pediatr Pulmonol. 2010; (1): 25-33
- A scientist track investigator program to support early career outcomes for clinician scientists. J Pediatr. 2009; (5): 603-4.e1
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