{"result":[{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Neal","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=29946&type=small&showNoImage","displayName":"James Neal","firstName":"James","href":"http://med.stanford.edu/profiles/postdocs/researcher/James_Neal","researchInterest":""},{"lastName":"Wei","clinicalFocus":[{"focus":"Hematology/Oncology/Stem Cell Transplant,  Pediatric"},{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Instructor,Pediatrics - Hematology & Oncology"}],"primaryAppointment":"Instructor,Pediatrics - Hematology & Oncology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=8537&type=small&showNoImage","displayName":"Michael Wei, MD, PhD","firstName":"Michael","href":"http://stanfordhospital.org/profiles/Michael_Wei","researchInterest":""},{"lastName":"Shah","clinicalFocus":[{"focus":"Inflammatory Bowel Diseases"},{"focus":"Gastroenterology"}],"appointments":[{"appointment":"Clinical Assistant Professor,Medicine - Gastroenterology & Hepatology"}],"primaryAppointment":"Clinical Assistant Professor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=10433&type=small&showNoImage","displayName":"Shamita B. Shah","firstName":"Shamita","href":"http://stanfordhospital.org/profiles/Shamita_Shah","researchInterest":"I joined Stanford after specialized training in Crohn's disease and ulcerative colitis.  I am the Clinical Director of the Inflammatory Bowel Disease Program.  My clinical and research interests within IBD include the application of novel diagnostic tools,  study of IBD-associated conditions, treatment of severe colitis, and prevention of post-operative recurrence."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor (Research),Medicine - Oncology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4307&type=small&showNoImage","displayName":"Shoshana Levy","firstName":"Shoshana","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Shoshana_Levy","researchInterest":"Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Jackson","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4463&type=small&showNoImage","displayName":"Peter Jackson","firstName":"Peter","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Peter_Jackson","researchInterest":"Cell cycle and cyclin control of DNA replication ."},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://stanfordhospital.org/profiles/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Mocarski","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4146&type=small&showNoImage","displayName":"Edward Mocarski","firstName":"Edward","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Edward_Mocarski","researchInterest":"My research interests focus on the biology and pathogenesis of cytomegalovirus (CMV), an opportunistic pathogen that causes significant disease worldwide. We developed global approaches and produced key insights into the areas of CMV gene regulation, DNA replication and packaging, maturation, impact on the host cell, disease pathogenesis, latency and reactivation, host cell signaling and chemokine system. These diverse findings address key aspects of the virus-host interaction."},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor (By courtesy),Natural Sciences Cluster - Chemistry"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Samos","clinicalFocus":[],"appointments":[{"appointment":"Science Writer/Editor,Neurosurgery"},{"appointment":"Information Editor,Neurosurgery"}],"primaryAppointment":"Science Writer/Editor,Neurosurgery","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=28093&type=small&showNoImage","displayName":"Cynthia Samos","firstName":"Cynthia","href":"http://stanfordhospital.org/profiles/Cynthia_Samos","researchInterest":""},{"lastName":"Soetikno","clinicalFocus":[{"focus":"Gastroenterology"}],"appointments":[],"imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4086&type=small&showNoImage","displayName":"Roy Soetikno, MD MS","firstName":"Roy","href":"http://stanfordhospital.org/profiles/Roy_Soetikno","researchInterest":"1. Epidemiology and biology of early colorectal cancer\r\n2. Development of new endoscopic technology and technique\r\n3. Outcomes of endoscopy"},{"lastName":"Mochly-Rosen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4256&type=small&showNoImage","displayName":"Daria Mochly-Rosen","firstName":"Daria","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Daria_Mochly-Rosen","researchInterest":"Two areas:  1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling.  We focus on protein kinase C (PKC)-mediated signal transduction and on mitochondrial dynamics in several disease models. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, we study their involvement  in normal cells and in models of human diseases."},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.  Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits."},{"lastName":"Friedland","clinicalFocus":[{"focus":"Endoscopy"},{"focus":"Gastroenterology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Gastroenterology & Hepatology"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Gastroenterology & Hepatology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=3873&type=small&showNoImage","displayName":"Shai Friedland","firstName":"Shai","href":"http://stanfordhospital.org/profiles/Shai_Friedland","researchInterest":"1. Gastrointestinal Endoscopy- Techniques and Outcomes\r\n2. Development of new endoscopic devices\r\n3. Diagnosis of intestinal ischemia\r\n4. High risk endoscopic resection"},{"lastName":"Nguyen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Stanford Cancer Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Stanford Cancer Institute","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=24227&type=small&showNoImage","displayName":"Le Xuan Truong Nguyen","firstName":"Le Xuan Truong","href":"http://med.stanford.edu/profiles/postdocs/researcher/Le Xuan Truong_Nguyen","researchInterest":""},{"lastName":"Rosen","clinicalFocus":[{"focus":"Pulmonology (Lung) and Critical Care "},{"focus":"Pulmonary Disease"}],"appointments":[{"appointment":"Associate Professor,Medicine - Pulmonary & Critical Care Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Medicine - Pulmonary & Critical Care Medicine","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4245&type=small&showNoImage","displayName":"Glenn Rosen","firstName":"Glenn","href":"http://stanfordhospital.org/profiles/Glenn_Rosen","researchInterest":"Our laboratory examines apoptotic and cell cycle pathways in cancer and lung disease. We have identified a novel cell cycle protein which regulates cell cycle progression in immune cells and the lung.  We are also studying signaling pathways that regulate cancer cell growth and metastasis."},{"lastName":"Tsai","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=33962&type=small&showNoImage","displayName":"Pei I Tsai","firstName":"Pei I","href":"http://med.stanford.edu/profiles/postdocs/researcher/Pei I_Tsai","researchInterest":""},{"lastName":"Gonzalez-Pena","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=24539&type=small&showNoImage","displayName":"Veronica Gonzalez-Pena","firstName":"Veronica","href":"http://med.stanford.edu/profiles/postdocs/researcher/Veronica_Gonzalez-Pena","researchInterest":""},{"lastName":"Kuo","clinicalFocus":[{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Chemical and Systems Biology"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=5906&type=small&showNoImage","displayName":"Calvin Kuo","firstName":"Calvin","href":"http://stanfordhospital.org/profiles/Calvin_Kuo","researchInterest":"We explore angiogenesis, cancer genomics, intestinal stem cells, and hepatic glucose metabolism.  Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy.  Intestinal stem cell projects use primary intestinal culture and mouse genetics to study injury-inducible vs homeostatic stem cells.  We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery."},{"lastName":"Sahoo","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Pathology - Stem Cell Institute"}],"primaryAppointment":"Instructor,Pathology - Stem Cell Institute","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=10888&type=small&showNoImage","displayName":"Debashis Sahoo","firstName":"Debashis","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Debashis_Sahoo","researchInterest":""}]}