{"result":[{"lastName":"Krueger","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pediatrics"}],"primaryAppointment":"Postdoctoral Research fellow, Pediatrics","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=16277&type=small&showNoImage","displayName":"Katherine Krueger","firstName":"Katherine","href":"http://med.stanford.edu/profiles/postdocs/researcher/Katherine_Krueger","researchInterest":""},{"lastName":"Sun","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Urology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor,Genetics"}],"primaryAppointment":"Associate Professor,Urology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4402&type=small&showNoImage","displayName":"Zijie Sun","firstName":"Zijie","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Zijie_Sun","researchInterest":"My lab focuses on understanding the molecular mechanism of transcription factors that govern the transformation of normal mammalian cells to a neoplastic state. We are especially interested in the action of the nuclear hormone receptors and the interactions between the receptors and other signaling pathways in related human disorders."},{"lastName":"Zarafshar","clinicalFocus":[{"focus":"Internal Medicine"}],"appointments":[{"appointment":"Clinical Instructor,Medicine - General Medical Disciplines"}],"primaryAppointment":"Clinical Instructor,Medicine - General Medical Disciplines","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=36463&type=small&showNoImage","displayName":"Shirin Zarafshar","firstName":"Shirin","href":"http://stanfordhospital.org/profiles/Shirin_Zarafshar","researchInterest":""},{"lastName":"Snyder","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=13465&type=small&showNoImage","displayName":"Michael Snyder","firstName":"Michael","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Michael_Snyder","researchInterest":"We are presently in an omics revolution in which genomes and other omes can be readily characterized. Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans.\r\n\r\n1) Transcriptomes\r\nTo annotate genomes, we developed RNA sequencing for annotation the yeast and human transcriptomes. We discovered that the eukaryotic transcriptome is much more complex than previously"},{"lastName":"Cao","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Biochemistry"}],"primaryAppointment":"Ph.D., Biochemistry","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=23857&type=small&showNoImage","displayName":"Shengya Cao","firstName":"Shengya","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Shengya_Cao","researchInterest":""},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://stanfordhospital.org/profiles/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Shin","clinicalFocus":[{"focus":"Cardiology (Heart), Pediatric"},{"focus":"Pediatric Cardiology"}],"appointments":[{"appointment":"Clinical Assistant Professor,Pediatrics - Cardiology"}],"primaryAppointment":"Clinical Assistant Professor,Pediatrics - Cardiology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=8592&type=small&showNoImage","displayName":"Andrew Young Shin","firstName":"Andrew","href":"http://stanfordhospital.org/profiles/Andrew_Shin","researchInterest":""},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Takahashi","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=23099&type=small&showNoImage","displayName":"Kazuhiro Takahashi","firstName":"Kazuhiro","href":"http://med.stanford.edu/profiles/postdocs/researcher/Kazuhiro_Takahashi","researchInterest":""},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Hanawalt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Dermatology"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=5957&type=small&showNoImage","displayName":"Philip C. Hanawalt","firstName":"Philip","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Philip_Hanawalt","researchInterest":"Our current research focuses in two principal areas:\r\n\r\n1. The molecular basis for  diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight  but  get no cancers. See Hanawalt & Spivak, 2008, for review.\r\n\r\n2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Cleary","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4506&type=small&showNoImage","displayName":"Michael Cleary","firstName":"Michael","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Michael_Cleary","researchInterest":"The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer."},{"lastName":"Kraemer","clinicalFocus":[{"focus":"Endocrinology / Diabetes"},{"focus":"Lipid Metabolism Disorders"},{"focus":"Endocrinology and Metabolism"}],"appointments":[{"appointment":"Professor,Medicine - Endocrinology, Gerontology, & Metabolism"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Endocrinology, Gerontology, & Metabolism","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4133&type=small&showNoImage","displayName":"Fredric Kraemer","firstName":"Fredric","href":"http://stanfordhospital.org/profiles/Fredric_Kraemer","researchInterest":"Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology."},{"lastName":"Yue","clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Cardiovascular Medicine"}],"appointments":[],"imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=8441&type=small&showNoImage","displayName":"Patrick Yue","firstName":"Patrick","href":"http://stanfordhospital.org/profiles/Patrick_Yue","researchInterest":"My primary research focus has been the mechanisms of insulin resistance and diabetes as they pertain to the heart.  I am particularly interested in the potential involvement of the recently discovered peptide hormone apelin.  Recent studies in my laboratory group have focused on apelin's role in promoting insulin sensitivity on the systemic, tissue-specific, and cellular level.  We are currently investigating apelin-mediated signaling events in insulin-sensitive and -resistant cardiac muscle."},{"lastName":"Cyert","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=6213&type=small&showNoImage","displayName":"Martha Cyert","firstName":"Martha","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Martha_Cyert","researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress."},{"lastName":"Lin","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Orthopaedic Surgery"}],"primaryAppointment":"Postdoctoral Research fellow, Orthopaedic Surgery","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=38115&type=small&showNoImage","displayName":"Tzu-hua Lin","firstName":"Tzu-hua","href":"http://med.stanford.edu/profiles/postdocs/researcher/Tzu-hua_Lin","researchInterest":""},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://stanfordhospital.org/profiles/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Albertelli","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Comparative Medicine"}],"primaryAppointment":"Assistant Professor - Med Center Line,Comparative Medicine","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=11414&type=small&showNoImage","displayName":"Megan Albertelli","firstName":"Megan","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Megan_Albertelli","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"},{"appointment":"Professor Emeritus,SoM Dean's Office Administrative Units - Dean's Office Operations"},{"appointment":"Professor Emeritus,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://stanfordhospital.org/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/stanfordhospital/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab's research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"}]}