Vincent Hentz

Publication Details

  • Collagenase clostridium histolyticum for Dupuytren's contracture EXPERT OPINION ON BIOLOGICAL THERAPY Desai, S. S., Hentz, V. R. 2010; 10 (9): 1395-1404


    Dupuytren's disease is a non-malignant, progressive disorder of the hands that can severely limit hand function and diminish overall quality of life. With global life expectancy increasing, the prevalence of this disease appears to be increasing amongst all ethnic groups. Treatment has traditionally remained surgical with few effective, nonsurgical options. However, with the introduction of collagenase clostridium histolyticum to treat Dupuytren's contractures, physicians and surgeons may be provided with a new, office-based, non-surgical option to treat this disease.The literature behind the use of collagenase to treat Dupuytren's disease; including its mechanism of action, safety, efficacy and clinical evidence behind its recent FDA approval.The latest information available on collagenase through a comprehensive review of PubMed and the websites of licensing organizations for medicinal products.Phase III, clinical trials on collagenase for treatment of Dupuytren's contractures have recently been completed. Meeting primary and secondary objectives, collagenase has obtained FDA approval for clinical use. Collagenase now provides a non-operative option for Dupuytren's disease. Although short-term results show that collagenase is safe and efficacious, long-term effects of repeat injections and contracture recurrence rates have yet to be examined.

    View details for DOI 10.1517/14712598.2010.510509

    View details for Web of Science ID 000281614500010

    View details for PubMedID 20666587

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