Sherry M. Wren

Publication Details

  • MIXED CHIMERISM TO INDUCE TOLERANCE FOR SOLID ORGAN-TRANSPLANTATION Wren, S. M., Nalesnik, M., HRONAKES, M. L., Oh, E., Ildstad, S. T. W B SAUNDERS CO-ELSEVIER INC. 1991: 439-443

    Abstract:

    Chimerism, or the coexistence of tissue elements from more than one genetically different strain or species in an organism, is the only experimental state that results in the induction of donor-specific transplantation tolerance. Transplantation of a mixture of T-cell-depleted syngeneic (host-type) plus T-cell-depleted allogeneic (donor) bone marrow into a normal adult recipient mouse (A + B----A) results in mixed allogeneic chimerism. Recipient mice exhibit donor-specific transplantation tolerance, yet have full immunocompetence to recognize and respond to third-party transplantation antigens. After complete hematolymphopoietic repopulation at 28 days, animals accept a donor-specific skin graft but reject major histocompatibility complex (MHC) locus-disparate third-party grafts. We now report that permanent graft acceptance can also be achieved when the graft is placed at the time of bone marrow transplantation. Histologically, grafts were viable and had only minimal inflammatory changes. This model may have potential future clinical application for the induction of donor-specific transplantation tolerance.

    View details for Web of Science ID A1991FF05500014

    View details for PubMedID 2056405

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