Michelle Cao

Publication Details

  • Advances in Narcolepsy MEDICAL CLINICS OF NORTH AMERICA Cao, M. 2010; 94 (3): 541-?


    Narcolepsy with cataplexy is a rare but life-long and challenging disorder. Current insight into the pathophysiology of this condition seems to be autoimmune-mediated postnatal cell death of hypocretin neurons occurring by organ-specific autoimmune targeting with HLA-T-cell receptor interactions. The hypocretin system seems to have an influence on multiple organ systems beyond its wake-promoting mechanisms. The recent availability of cerebrospinal fluid hypocretin-1 analysis has led to definitive diagnostic criteria for narcolepsy with cataplexy. Pharmacologic first-line treatments for excessive daytime sleepiness and cataplexy is sodium oxybate, with modafinil for daytime sleepiness, in adults and children. Other investigative agents and treatment modalities hold promise in future directions for narcolepsy.

    View details for DOI 10.1016/j.mcna.2010.02.008

    View details for Web of Science ID 000278853600008

    View details for PubMedID 20451031

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