Catherine Blish

Publication Details

  • Changes in Plasma Cytokines after Treatment of Ascaris lumbricoides Infection in Individuals with HIV-1 Infection JOURNAL OF INFECTIOUS DISEASES Blish, C. A., Sangare, L., Herrin, B. R., Richardson, B. A., John-Stewart, G., Walson, J. L. 2010; 201 (12): 1816-1821

    Abstract:

    Albendazole treatment of individuals with human immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides co-infection has led to significantly improved CD4(+) cell counts and a trend for lower plasma HIV-1 RNA levels in a previous randomized placebo-controlled trial. To define mechanisms by which deworming contributed to changes in markers of HIV-1 disease progression, plasma cytokine levels were evaluated. Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .01)ot associated with significant changes in levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon gamma, tumor necrosis factor alpha, or thymic stromal lymphopoietin. Treatment of A. lumbricoides co-infection may delay HIV-1 disease progression by reducing helminth-induced, IL-10-mediated immunosuppression.

    View details for DOI 10.1086/652784

    View details for Web of Science ID 000277687900007

    View details for PubMedID 20441516

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