Matthew Anderson
Publication Details
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HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.
PLoS One. 2008; (11): e3722
HLA-DM (DM) mediates exchange of peptides bound to MHC class II (MHCII) during the epitope selection process. Although DM has been shown to have two activities, peptide release and MHC class II refolding, a clear characterization of the mechanism by which DM facilitates peptide exchange has remained elusive.
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