David N. Cornfield

Publication Details

  • Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature Cornfield, D. N. SPRINGER-VERLAG BERLIN. 2010: 201-220


    The increase in oxygen tension occurring at birth causes sustained and progressive pulmonary vasodilation. The oxygen-induced perinatal pulmonary vasodilation depends on the production of nitric oxide (NO) from the pulmonary endothelium and activation of various K(+) channels in pulmonary artery smooth muscle cells. This chapter reviews a) the oxygen-sensing mechanism that stimulates endothelial NO production; b) how K(+) channels sense changes in oxygen tension; c) whether hypoxia-inducible factor-1alpha (HIF-1alpha), a well defined hypoxia-sensitive transcription factor in adult, contributes to the regulation of NO production and K(+) channel activation; and d) whether and how dysfunctional K(+) channels contribute to the development of pulmonary hypertension in the newborns.

    View details for DOI 10.1007/978-1-60761-500-2_13

    View details for Web of Science ID 000293426500013

    View details for PubMedID 20204732

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