Julie Tinklenberg

Publication Details

  • PERTUSSIS TOXIN AND 4-AMINOPYRIDINE DIFFERENTIALLY AFFECT THE HYPNOTIC ANESTHETIC ACTION OF DEXMEDETOMIDINE AND PENTOBARBITAL ANESTHESIOLOGY Doze, V. A., Chen, B. X., Tinklenberg, J. A., SEGAL, I. S., Maze, M. 1990; 73 (2): 304-307

    Abstract:

    Dexmedetomidine, a highly selective and potent agonist at alpha-2 adrenoceptors, produces a hypnotic-anesthetic action in rats. The mechanism for this response may involve an inhibitory G-protein and increased conductance through a potassium channel. To investigate this, the effects of pertussis toxin, a specific inactivator of inhibitory G-proteins, and 4-aminopyridine, a blocker of potassium channels, on the hypnotic-anesthetic response to dexmedetomidine were studied in rats. Pertussis toxin and 4-aminopyridine both decreased the hypnotic-anesthetic action of dexmedetomidine in a dose-dependent fashion. To preclude the possibility that pertussis toxin and 4-aminopyridine attenuated the hypnotic-anesthetic action of dexmedetomidine via indirect central nervous system excitation, the effects of pertussis toxin and 4-aminopyridine on the hypnotic-anesthetic action of pentobarbital also were assessed. Pentobarbital-induced hypnosis was not attenuated by either treatment. These results suggest that the receptor-effector mechanism for the hypnotic-anesthetic action of dexmedetomidine involves an inhibitory G-protein and increased conductance through a potassium channel.

    View details for Web of Science ID A1990DV59100019

    View details for PubMedID 1974396

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