Uta Francke

Publication Details

  • STRUCTURE AND CHROMOSOMAL MAPPING OF A HIGHLY POLYMORPHIC REPETITIVE DNA-SEQUENCE FROM THE PSEUDOAUTOSOMAL REGION OF THE MOUSE SEX-CHROMOSOMES CYTOGENETICS AND CELL GENETICS Harbers, K., FRANCKE, U., Soriano, P., Jaenisch, R., Muller, U. 1990; 53 (2-3): 129-133

    Abstract:

    The pseudoautosomal region of the Mov15 mouse strain is marked by a Moloney murine leukemia provirus. The sequences flanking the Mov15 provirus were molecularly cloned and shown to consist of a tandemly repeated sequence of 31 nucleotides. Copy number variation of this repeat most likely accounts for the polymorphism in the mouse pseudoautosomal region detected with a probe from the flanking sequences. In situ hybridization to metaphase chromosomes showed heavy labeling of the pairing region of the X and Y chromosomes. The repetitive sequence was also found at the subtelomeric region of three autosomes. A similar level of amplification as the one seen on the sex chromosomes seems to be present on chromosomes 9 and 13. Lower copy number appear to be present on chromosome 4.

    View details for Web of Science ID A1990DL00300015

    View details for PubMedID 1973377

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