Steven Shafer
Publication Details
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A model of the ventilatory depressant potency of remifentanil in the non-steady state.
Anesthesiology. 2003; (4): 779-87
The C50 of remifentanil for ventilatory depression has been previously determined using inspired carbon dioxide and stimulated ventilation, which may not describe the clinically relevant situation in which ventilatory depression occurs in the absence of inspired carbon dioxide. The authors applied indirect effect modeling to non-steady state Paco2 data in the absence of inspired carbon dioxide during and after administration of remifentanil.
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