Mark Holodniy

Publication Details

  • The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS QUALITY OF LIFE RESEARCH Nosyk, B., Sun, H., Bansback, N., Guh, D. P., Li, X., Barnett, P., Bayoumi, A., Griffin, S., Joyce, V., Holodniy, M., Owens, D. K., Anis, A. H. 2009; 18 (7): 815-824


    To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.

    View details for DOI 10.1007/s11136-009-9504-0

    View details for Web of Science ID 000268881000003

    View details for PubMedID 19562514

Stanford Medicine Resources:

Footer Links: