Steven Artandi

Publication Details

  • TCAB1 Driving telomerase to Cajal bodies CELL CYCLE Venteicher, A. S., Artandi, S. E. 2009; 8 (9): 1329-1331


    Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo. TCAB1 is a component of active telomerase and is required for the telomerase holoenzyme to accumulate in Cajal bodies and to elongate telomeres. These findings provide important new insights into how telomerase functions in cancer and in stem cell biology.

    View details for Web of Science ID 000266114600016

    View details for PubMedID 19342896

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