Anthony G. Doufas, M.D., Ph.D.

Publication Details

  • Reinforcement learning versus proportional-integral-derivative control of hypnosis in a simulated intraoperative patient.

    Moore BL, Quasny TM, Doufas AG. Anesth Analg. 2011; 112 (2): 350-9

    Research has demonstrated the efficacy of closed-loop control of anesthesia using bispectral index (BIS) as the controlled variable. Model-based and proportional-integral-derivative (PID) controllers outperform manual control. We investigated the application of reinforcement learning (RL), an intelligent systems control method, to closed-loop BIS-guided, propofol-induced hypnosis in simulated intraoperative patients. We also compared the performance of the RL agent against that of a conventional PID controller.

    PubMedID: 21156973

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