Eswar Krishnan, MD M.Phil

Publication Details

  • What constitutes progress in assessing patient outcomes? JOURNAL OF CLINICAL EPIDEMIOLOGY Fries, J. F., Krishnan, E. 2009; 62 (8): 779-780


    Patient self-reported disability outcomes, measured using instruments such as the Health Assessment Questionnaire Disability Index (HAQ-DI) form a foundation for clinical studies of several conditions, notably arthritis. These instruments are "static" because the instrument is the same in all applications. Although generally performing well, they may fail at extremes of disability, the so-called floor and ceiling effects. Another limitation is the degree of measurement error, the signal-to-noise ratio. These two issues drive down the statistical power of clinical trials and increase their expense.

    View details for DOI 10.1016/j.jclinepi.2008.12.001

    View details for Web of Science ID 000268200300001

    View details for PubMedID 19282147

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