Sean McGhee

Publication Details

  • Immunologic reconstitution in 22q deletion (DiGeorge) syndrome IMMUNOLOGIC RESEARCH McGhee, S. A., Lloret, M. G., Stiehm, E. R. 2009; 45 (1): 37-45


    Adoptive transfer of mature T cells (ATMTC) through bone marrow (BM) transplantation, first attempted over 20 years ago, has recently emerged as a successful therapy for complete 22q deletion syndrome (22qDS). This provides a potential option to thymic transplantation (TT) for immune reconstitution in 22qDS. Compared to thymic transplant, ATMTC is an easier procedure to accomplish and is available at more centers. However, there are differences in the nature of the T-cell reconstitution that results. Predictably, more naïve T cells and recent thymic emigrants are present in patients treated with thymus transplant. There are no significant differences in mortality between the two procedures, but the number of patients is too limited to conclude that the procedures are equally effective. Adoptive transfer should be pursued as a reasonable treatment for 22qDS patients requiring immune reconstitution when thymus transplant is not available.

    View details for DOI 10.1007/s12026-009-8108-7

    View details for Web of Science ID 000269904000004

    View details for PubMedID 19238335

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