Christian Guilleminault

Publication Details

  • Problems associated with switch to modafinil - a novel alerting agent in narcolepsy EUROPEAN JOURNAL OF NEUROLOGY Guilleminault, C., Aftab, F. A., Karadeniz, D., Philip, P., Leger, D. 2000; 7 (4): 381-384


    Modafinil is a novel medication recently approved for the treatment of narcolepsy and idiopathic hypersomnia. Commonly, patients had already been prescribed medications for their syndrome. This report outlines difficulties encountered in the clinical practice of switching patients to modafinil. Naïve subjects accepted modafinil best. Subjects withdrawn from amphetamine had the most problems and failure to withdraw. Venlafaxine hydrochloride combined well with modafinil to control cataplectic attacks. Usage of a progressive withdrawal protocol may ease the difficulties observed.

    View details for Web of Science ID 000088697000002

    View details for PubMedID 10971596

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