C. Garrison Fathman

Publication Details

  • ANTI-CD4 MEDIATES CLONAL ANERGY DURING TRANSPLANTATION TOLERANCE INDUCTION JOURNAL OF EXPERIMENTAL MEDICINE Alters, S. E., Shizuru, J. A., Ackerman, J., Grossman, D., Seydel, K. B., Fathman, C. G. 1991; 173 (2): 491-494

    Abstract:

    Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.

    View details for Web of Science ID A1991EV17500025

    View details for PubMedID 1899105

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