Gordon O. Matheson

Publication Details

  • CARDIOVASCULAR ADAPTATIONS IN ANDEAN NATIVES AFTER 6 WK OF EXPOSURE TO SEA-LEVEL JOURNAL OF APPLIED PHYSIOLOGY McKenzie, D. C., Goodman, L. S., Nath, C., Davidson, B., Matheson, G. O., Parkhouse, W. S., Hochachka, P. W., Allen, P. S., Stanley, C., Ammann, W. 1991; 70 (6): 2650-2655


    Six male Quechua Indians (34.0 +/- 1.1 yr, 159.5 +/- 2.1 cm, 60.5 +/- 1.6 kg), life-long residents of La Raya, Peru (4,350-m altitude with an average barometric pressure of 460 Torr), were studied using noninvasive methods to determine the structural and functional changes in the cardiovascular system in response to a 6-wk deacclimation period at sea level. Cardiac output, stroke volume, and left ventricular ejection fractions were determined using radionuclide angiographic techniques at rest and during exercise on a cycle ergometer at 40, 60, and 90% of a previously determined maximal O2 consumption. Subjects at rest were subjected to two-dimensional and M-mode echocardiograms and a standard 12-lead electrocardiogram. Hemoglobin and hematocrit were measured on arrival at sea level by use of a Coulter Stacker S+ analyzer. After a 6-wk deacclimation period, all variables were remeasured using the identical methodology. Hemoglobin values decreased significantly over the deacclimation period (15.7 +/- 1.1 to 13.5 +/- 1.2 g/dl; P less than 0.01). The results indicate that the removal of these high-altitude-adapted natives from 4,300 m to sea level for 6 wk results in only minor changes to the cardiac structure and function as measured by these noninvasive techniques.

    View details for Web of Science ID A1991FQ58600039

    View details for PubMedID 1885461

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