Paul C. Grimm

Publication Details

  • SENSITIZED LYMPHOCYTES-B CONTRIBUTE TO ACUTE ALLOGRAFT-REJECTION JOURNAL OF SURGICAL RESEARCH Gritsch, H. A., Grimm, P. C., Ettenger, R. B., Rosenthal, J. T. 1991; 51 (3): 204-209

    Abstract:

    The contribution of sensitized B lymphocytes to second-set allograft rejection has been relatively ignored despite their regular appearance in rejecting allografts. This study presents evidence that adoptively transferred sensitized B lymphocytes accelerate the rate of acute allograft rejection in a sublethally irradiated rat cardiac allograft model. Donors of reconstituting B lymphocytes were sensitized with three consecutive ACI skin grafts. Transplantation of a heart from an ACI strain donor into a Lewis strain recipient (complete RT1 mismatch) results in rejection in 6.8 +/- 0.3 days. When the allograft donor and recipient are irradiated with 650 cGy prior to transplantation, rejection occurs at 31.5 +/- 3.0 days. Irradiated recipients reconstituted with 10(6) syngeneic sensitized splenic B cells reject their grafts in 20.1 +/- 2.0 days, while reconstitution with 10(6) unsensitized syngeneic B cells has no effect on the rate of rejection (P = 0.0007). These data strongly suggest that sensitized B lymphocytes have a marked accelerating effect on the tempo of allograft rejection.

    View details for Web of Science ID A1991GD58000005

    View details for PubMedID 1881134

Stanford Medicine Resources:

Footer Links: