John W. Farquhar, M.D.

Publication Details

  • DISTRIBUTION OF PLASMA LIPOPROTEINS IN MIDDLE-AGED MALE RUNNERS METABOLISM-CLINICAL AND EXPERIMENTAL Wood, P. D., Haskell, W., Klein, H., Lewis, S., Stern, M. P., Farquhar, J. W. 1976; 25 (11): 1249-1257


    Stimulated by increasing evidence of an inverse relationship between plasma high-density lipoprotein cholesterol level and frequency of coronary heart disease, we determined concentrations of fasting plasma cholesterol, triglyceride, and lipoproteins in 41 very active men (running greater than 15 miles/wk for the previous year) 35-59 years of age (mean age, 47) and in a comparison group of men of similar age, randomly selected from three northern California communities. The runners had significantly (p less than 0.05) decreased mean plasma triglyceride (70 versus 146 mg/100 ml), total plasma cholesterol (200 versus 210 mg/100 ml), and low-density lipoprotein (LDL) cholesterol (125 versus 139 mg/100 ml) concentrations, and a higher mean level of high-density lipoprotein (HDL) cholesterol (64 versus 43 mg/100 ml) than the comparison group (n equals 147 for HDL and LDL; n equals 743 for total cholesterol and triglycerides). These very active men exhibited a plasma lipoprotein profile resembling that of younger women rather tan of sedentary, middle-aged men. This characteristic, and apparently advantageous, pattern could be only partially accounted for by differences in adiposity between runners and control subjects.

    View details for Web of Science ID A1976CL12700008

    View details for PubMedID 185487

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