Stephen Galli

Publication Details

  • Immunomodulatory mast cells: negative, as well as positive, regulators of immunity NATURE REVIEWS IMMUNOLOGY Galli, S. J., Grimbaldeston, M., Tsai, M. 2008; 8 (6): 478-U14


    Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.

    View details for DOI 10.1038/nri2327

    View details for Web of Science ID 000256105700018

    View details for PubMedID 18483499

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