Samuel Strober

Publication Details

  • IDENTIFICATION OF A FACTOR(S) FROM CLONED MURINE NATURAL SUPPRESSOR CELLS THAT INHIBITS IL-2 SECRETION DURING ANTIGEN-DRIVEN T-CELL ACTIVATION CELLULAR IMMUNOLOGY VANVLASSELAER, P., Niki, T., Strober, S. 1991; 138 (2): 326-340

    Abstract:

    Crude supernatants were obtained from cloned murine natural suppressor (NS) cells activated in vitro with phorbol-myristate-acetate (PMA) and calcium ionophore (A23187). Supernatants suppressed IL-2 production in the mixed leukocyte reaction (MLR) with BALB/c spleen cells, but no reduction was observed in the response to PHA, Con A, or anti-CD3 antibody. Suppressive activity was partially purified by DEAE ion exchange chromatography, and inhibited the antigen-presenting function of the macrophage line 1G18-LA in an assay system with the ovalbumin-specific T cell hybridoma, 3DO-18.3. In addition, the antigen-presenting function of the A20 B cell line was inhibited in an assay with a sperm whale myoglobin (SpWMb)-specific T cell hybridoma (8.2.1d.H1a). Results with blocking antibodies suggest that this factor appears to be a unique cytokine.

    View details for Web of Science ID A1991GP54900006

    View details for PubMedID 1834346

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